Table 1. Apparent Permeability (Papp), Transport Ratio (TR), and Corrected Transport Ratio (cTR) Values from In Vitro Bidirectional Transport Studies.
| Cell type | Treatment (P-gp inhibitor) | Papp A→B ( × 10−6 cm/s) | Papp B→A ( × 10−6 cm/s) | TR | cTR |
|---|---|---|---|---|---|
| MDCKII-WT | None | 7.75±0.33 | 18.00±0.51 | 2.32 | N/A |
| MDCKII-MDR1 | None | 2.11±0.10 | 15.23±0.51 | 7.22a | 3.11a |
| MDCKII-MDR1 | Verapamil (200 μM) | 4.87±0.65 | 7.36±1.13 | 1.51 | N/A |
| MDCKII-MDR1 | CsA (25 μM) | 3.35±0.39 | 11.12±0.42 | 3.33 | N/A |
a
Exceeds predefined threshold for identification of a transported P-gp substrate (Polli et al, 2001; Schwab et al, 2003; Zhang et al, 2006).