Table 2. Escitalopram Concentrations in Plasma and Brain Tissue, and Brain Tissue : Plasma Escitalopram Concentration Ratios at Termination of In Vivo Pharmacokinetic Studies.

Group	Plasma (ng/ml)	Prefrontal cortex		Hippocampus
		(ng/g)	B:Pa ratio	(ng/g)	B:Pa ratio
Escit+VEH	709±26	7074±438	10.09±0.87	7999±638	11.43±1.19
Escit+CsA	678±76	21 827±1658	33.59±4.09	20 432±927	31.48±3.48
p-Value	0.709	<0.001***	0.004**	<0.001***	0.001**

n=5 per group.

**p<0.01.

***p<0.001.

^aBrain region : plasma ratio.