Figure 2.

Impact of citalopram on paired associative stimulation (PAS)-induced neuroplasticity. Shown are baseline-normalized MEP amplitudes after plasticity induction by PAS25 (a) and PAS10 (b) under placebo or citalopram medication conditions up to the evening of the post-stimulation day. (a) In the placebo medication condition, PAS25 induced a significant excitability elevation up to 60 min after stimulation, which was enhanced, but not prolonged, by citalopram. (b). In the placebo medication condition, cortical excitability was significantly reduced after PAS10, this effect was abolished by citalopram. Error bars indicate SEM. Filled symbols indicate significant differences of post-stimulation MEP amplitudes from respective baseline values; asterisks indicate significant differences between the drug and placebo medication conditions at the same time points (Student's t-test, two-tailed, paired samples, p<0.05).