Figure 2.

(a) p21 expression correlates with patient age. There was a significant positive correlation between p21 expression and age in depressed women (r=0.70, p=0.016) but not men (r=0.42, p=0.15). Age and p21 expression were not significantly correlated with each other in control or depressed patients with psychotic symptoms but were significantly positively correlated in depressed patients without psychotic symptoms (r=0.61, p=0.037). (b) NeuN density correlates with age of onset of depression. There was a significant positive correlation between NeuN density in the GCL of the hippocampus and age of onset of depression. However, this correlation was only significant in depressed patients with psychosis (r=0.61, p=0.035).