FIG. 7.

Model depicting Odd and Ush regulation of lymph gland prohemocyte differentiation. Odd and Srp are negatively regulated by Dpp signaling (red blocked line). Dpp inhibition of srp expression leads to loss of ush expression. Conversely, ush expression is maintained by the combined activities of Srp and JAK/STAT signaling. Ush and Odd act in separate pathways to maintain prohemocyte (PH) potency by blocking differentiation. Odd blocks the differentiation of plasmatocytes (PM) and lamellocytes (LM). Ush blocks the differentiation of all three blood cell types, plasmatocytes, crystal cells (CC) and lamellocytes. Green arrows and blocked lines depict pathways that maintain prohemocyte multipotency. Grey lines depict differentiation pathways. The lymph gland medullary zone (MZ) is depicted in grey and cortical zone (CZ) is depicted in yellow. Abbreviations: dpp, decapentaplegic; odd, odd-skipped; srp, serpent; ush, u-shaped.