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. 2013 Aug 27;110(37):15097–15102. doi: 10.1073/pnas.1306884110

Fig. 1.

Fig. 1.

The neurokinin3-receptor agonist, senktide, improves object-place and water-maze learning in aged rats. Object-place recognition and water-maze learning of aged rats treated with vehicle + vehicle (VE +VE), 3 mg/kg SR142801+vehicle (3 mg SR + VE), 6 mg/kg SR142801 + vehicle (6 mg SR + VE), vehicle + 0.2 mg/kg senktide (VE + Senk), 3 mg/kg SR142801 + 0.2 mg/kg senktide (3 mg SR + Senk), or 6 mg/kg SR142801+0.2 mg/kg senktide (6 mg SR + Senk). (A) Object-place recognition design. The schematic picture shows possible object locations in the object-place recognition task. The animals received two trials with a 5-min duration and an intertrial interval (ITI) of 25 min. During the test trial, two objects known from the sample trial were presented, one in a novel position (A1, spatial displaced) and one in the same position (A2, spatial stationary) relative to the sample trials. (B) Object-place recognition. The data are represented as means plus SE of object-exploration time (seconds) of spatial stationary and spatial displaced objects in the test trial (#P < 0.01). (C) Water maze: mean escape latencies onto a hidden platform over 12 trials of water-maze acquisition of aged rats (#P < 0.01; $P < 0.001 vs. VE + VE).