Children with the der(8)t(8;12) exhibit features including a thin upper lip, short nose, periorbital fullness, malar hypoplasia, narrow palpebral fissures, high forehead, and prominent chin. Facial features of subject 1 at (A) 22 mo, (B) 5 y, and (C) 13 y; subject 2 at (D) 4 y, (E) 11 y, and (F) 15 y; subject 3 at (G) 4 y and (H) 11 y; (I) subject 4 at 9 y; (J) subject 6 at 4 y; and (K) subject 7 at 5 y are shown. (L) Pedigrees of 7 families. Filled symbols indicate affected individuals with the unbalanced translocation.