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Effect of the nitric oxide synthase inhibitor l-NAME on cardioprotection induced by arginase inhibition in rat hearts. Recovery of LVDP and LVEDP during reperfusion is shown. l-NAME (0.1 mM) or vehicle was added in blood 5 min before nor-NOHA (1 mM) or vehicle and administered at the onset of ischemia. Data are shown as mean ± SEM (n = 6–16). Significance denotes difference between the group given nor-NOHA + vehicle and the other groups (two-way ANOVA).
