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. 2013 Jun 17;2(3):243–255. doi: 10.1016/j.molmet.2013.06.003

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© 2013 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Gene–gene interaction between TCF7L2 and NR4A3. The effects of NR4A3 SNP rs12686676 and TCF7L2 SNP rs7903146 in our overall cohort are shown in (A) and (B), respectively. Thereafter, we stratified our cohort according to TCF7L2 SNP rs7903146 in order to assess the effect of NR4A3 SNP rs12686676 in both subgroups separately (C). Both SNPs, TCF7L2 SNP rs7903146 and NR4A3 SNP rs12686676, are presented in the dominant inheritance model. We adjusted for possible confounders (gender, age, and BMI). Data are given as mean±SEM.