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. Author manuscript; available in PMC: 2013 Sep 16.
Published in final edited form as: Nat Prod Rep. 2009 Aug 13;26(10):1321–1344. doi: 10.1039/b810774m

Table 3.

Structures and anti-HIV activity of C-3- and/or C-28-modified betulinic acid (1) derivatives 161–170a

graphic file with name nihms509793t1.jpg
No. R1 R2 IC50 (µM)
161 (Bevirimat) DSB OH 0.00035196
0.0013197
0.011205
162 graphic file with name nihms509793t2.jpg OH 0.0087197
163 graphic file with name nihms509793t3.jpg OH 0.12197
9 H graphic file with name nihms509793t4.jpg 0.053202
164 H graphic file with name nihms509793t5.jpg 0.05–2.00199
165 H -NH-(CH2)7-NHCOCH3 0.047202
166 DSB -NH-(CH2)7-NHCOCH3 0.0026202
167 DSB graphic file with name nihms509793t6.jpg 0.007205
168 DSB graphic file with name nihms509793t7.jpg 0.006205
169 DSB graphic file with name nihms509793t8.jpg 0.006206
170 DSB graphic file with name nihms509793t9.jpg 0.003206
a

DSB: 3′,3′-dimethylsuccinyl.