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. 2013 Jun 4;2(3):227–242. doi: 10.1016/j.molmet.2013.05.006

Figure 5.

Figure 5

Adipocyte ERα regulates the capacity of estradiol-17β to modulate body weight and adipose tissue distribution. All females were OVX and administered VEH or estradiol-17β at 12 weeks and all post-sacrifice measurements were taken in 18-week-old mice, 42 days post-OVX (n=8/genotype). (A and B) Daily body weight was measured in singly housed female mice post-OVX on normal chow (n=8/genotype). (C) Daily food intake was measured in singly housed female mice post-OVX on normal chow (n=8/genotype). (D and E) Body composition was in 30-day post-OVX chow fed females (n=8/genotype). (F) At the time of sacrifice (42 days post-OVX), bilateral gonadal fat pads were weighed. Data presented as a fold change over VEH of pad weight/mouse body weight. (G and H) Oral glucose tolerance test (OGTT) was performed in 16-week-old females (n=8/genotype), 30 days post-OVX. (I) Area under the curve (AUC) was calculated for the OGTTs. Data are presented as mean±SEM, and *P<0.05 between WT and AdipoERα mice and # P<0.05 between VEH and 17β-estradiol.