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. 2013 Jun 11;2(3):256–269. doi: 10.1016/j.molmet.2013.06.001

Figure 6.

Figure 6

Changes in T-cell repertoire in response to HFFD and MLDL1278a treatment. (A) HFFD reduced populations of CD4 Naïve T-cells, which was reversed by treatment with MLDL1278a. (B) CD4 Central Memory T-cells were increased in HFFD animals, and returned to control levels when treated with MLDL1278a. CD4 effector memory T-cells (C) and CD8 Naïve T-cells (D) were not altered by diet or treatment. (E and F). Central and Effector memory T-cells were not affected by diet, however treatment induced a significant shift in T-cell population from Effector to Central Memory T-cells. Values represent the mean±SEM. Student t-test for diet effect (Pre versus control; ♯=p<0.05) and repeated measures ANOVA for effect of treatment (*=p<0.05, **=p<0.01, ***=p<0.001 with Bonferroni post hoc testing).