Table 2.
Outcomes in both groups at baseline, week 2 and month 6 with group differences as indicators of change.
| Integrative medicine group | Conv. rheumatology group | Mean difference | Mean diff. (95% CI) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Baseline (n = 21) |
Visit 2 (n = 20) |
Visit 3 (n = 18) |
Baseline (n = 11) |
Visit 2 (n = 11) |
Visit 3 (n = 7) |
∇ 1-2 (95% CI) | P value | ∇ 1–3 (95% CI) | P value | |
| FIQ score | 46.9 ± 12.6 | 32.8 ± 14.0 | 36.5 ± 17.1 | 51.0 ± 12.2 | 38.1 ± 8.7 | 40.7 ± 14.6 | 1.30 (−6.00; 8.59) | 0.72 | 2.97 (−6.26; 12.20) | 0.51 |
| Pain score (NRS) | 6.0 ± 1.9 | 4.2 ± 2.5 | 4.2 ± 2.8 | 6.7 ± 2.5 | 5.7 ± 2.1 | 6.3 ± 2.3 | 0.89 (−0.87; 2.65) | 0.31 | 2.08 (−0.52; 4.69) | 0.11 |
| Quality of sleep | 4.0 ± 1.9 | 4.7 ± 2.7 | 5.1 ± 2.5 | 3.5 ± 3.1 | 4.5 ± 2.7 | 5.3 ± 3.9 | 0.09 (−2.52; 2.70) | 0.94 | 0.17 (−2.99; 3.33) | 0.91 |
| HADS anxiety | 8.8 ± 3.6 | 5.7 ± 3.7 | 8.1 ± 3.4 | 9.0 ± 3.8 | 8.1 ± 4.3 | 9.3 ± 4.8 | 2.09 (−0.66; 4.84) | 0.13 | 1.48 (−2.05; 5.00) | 0.40 |
| HADS depression | 7.4 ± 3.4 | 4.3 ± 2.4 | 7.1 ± 2.5 | 7.4 ± 3.6 | 7.3 ± 4.0 | 9.7 ± 5.0 | 2.86 (0.67; 5.05) | 0.01 | 2.43 (−0.37; 5.22) | 0.09 |
| SES sensory pain perception | 20.9 ± 5.8 | 16.6 ± 4.0 | 19.8 ± 6.8 | 20.7 ± 6.0 | 21.1 ± 7.2 | 19.5 ± 5.2 | 0.61 (−4.73; 5.95) | 0.82 | 2.72 (−3.97; 9.40) | 0.41 |
| SES affective pain perception | 31.7 ± 8.4 | 26.4 ± 9.6 | 28.9 ± 10.6 | 34.6 ± 9.2 | 30.0 ± 7.9 | 36.0 ± 11.1 | 4.61 (−0.15; 9.38) | 0.06 | 0.87 (−5.06; 6.80) | 0.76 |
| STAI state score | 52.4 ± 6.0 | 44.1 ± 14.2 | 49.6 ± 8.6 | 50.7 ± 11.2 | 42.1 ± 7.0 | 53.9 ± 13.0 | −0.44 (−9.75; 8.87) | 0.92 | 7.97 (−0.19; 16.13) | 0.06 |
| STAI trait score | 45.9 ± 11.5 | 39.7 ± 10.4 | 44.3 ± 11.1 | 46.8 ± 11.4 | 45.4 ± 11.2 | 50.7 ± 13.0 | 4.40 (−4.14; 12.93) | 0.30 | 6.44 (−7.08; 19.95) | 0.33 |
Values are mean ± SD if not indicated otherwise. SBP: systolic blood pressure; DBP: diastolic blood pressure.
STAI: state and trait anxiety questionnaire, FIQ: fibromyalgia impact questionnaire; NRS: numeric rating scale 0–10; HADS: hospital anxiety and depression scale; ∇ 1-2: difference between groups from baseline to visit 2 at 2 weeks, ∇ 1–3: difference between groups from baseline to visit 3 at 12 weeks. SES: pain perception scale.
*P values for between-group difference of change are adjusted.