Table 2. Association of the three lead signals related to head circumference with additional phenotypes.

Marker	Head circumference in third trimester of pregnancy (SD score)				Head circumference at birth (SD score)				Intra cranial volume (ml)
	Total N	Beta	Se	P-value	Total N	Beta	Se	P-value	TotalN	Mean age at measurement (years)	Beta	Se	P-value
rs7980687_A on 12q24	3,781	0.089	0.029	1.9×10−3	17,330	0.050	0.012	5.2×10−5	8,175	67.5	0.72	2.03	0.72
rs1042725_Ton 12q15	3,781	−0.075	0.023	9.9×10−4	17,074	−0.031	0.010	1.9×10−3	8,175	67.5	−7.18	1.61	8.8×10−6
rs11655470_T on 17q21	3,781	0.049	0.024	0.037	17,695	0.030	0.010	2.0×10−3	8,175	67.5	3.54	1.69	0.036 #

SD; standard deviation, Se; standard error, Beta’s reflect difference in head circumference SD score per minor allele, or difference in intra cranial volume (ml) per minor allele (additive model). P value is obtained from linear regression the SNP and sex against of head circumference SD score in fetal life (additive model); SNP, sex and gestational age at against birth head circumference SD score at birth (additive model); SNP, age and sex against Intra cranial volume (ml) (additive model)². All study samples were of European descent.

^#A variant further downstream (rs9915547; r² 0.22 HapMap CEU) showed a genome-wide significant association (P=1.5×10⁻¹²) with adult intra cranial volume.²