Table 1.

Genomic location and association test results for the sentinel SNPs from the six loci reaching P<5×10⁻⁸ amongst South Asians. Results are provided as odds ratio [OR] (95% confidence interval) per copy of risk allele.

				RAF		GWA South Asians			Replication South Asians		Combined analysis South Asians		Europeans (DIAGRAM+)			Global analysis
SNP	Chr (position)	Nearest Gene	Alleles (A/R)	SA	EW	N	OR	P	OR	P	OR	P	OR	P	Phetero	OR	P
rs3923113	2 (165210095)	GRB14	C / A	0.74	0.64	18,174	1.15 (1.09-1.21)	3.7 ×10−7	1.07 (1.03-1.11)	6.7 ×10−4	1.09 (1.06-1.13)	1.0 ×10−8	1.05 (1.01-1.10)	2.0 ×10−2	0.64	1.08 (1.05-1.11)	1.6 ×10−9
rs16861329	3 (188149155)	ST6GAL1	A / G	0.75	0.86	18,186	1.12 (1.07-1.19)	2.3 ×10−5	1.07 (1.03-1.11)	1.6 ×10−4	1.09 (1.06-1.12)	3.4 ×10−8	1.02 (0.95-1.09)	0.62	0.21	1.08 (1.05-1.11)	1.3 ×10−7
rs1802295	10 (70601480)	VPS26A	G / A	0.26	0.31	15,506*	1.14 (1.08-1.20)	1.9 ×10−6	1.06 (1.03-1.10)	6.6 ×10−4	1.08 (1.05-1.12)	4.1 ×10−8	1.04 (1.00-1.09)	6.0 ×10−2	0.50	1.07 (1.05-1.10)	2.1 ×10−8
rs7178572	15 (75534245)	HMG20A	A / G	0.52	0.71	18,193	1.10 (1.05-1.15)	2.4 ×10−5	1.08 (1.05-1.12)	7.0 ×10−7	1.09 (1.06-1.12)	7.1 ×10−11	1.07 (1.02-1.12)	2.6 ×10−3	0.59	1.08 (1.06-1.11)	9.2 ×10−13
rs2028299	15 (88175261)	AP3S2	A / C	0.31	0.31	18,076	1.11 (1.05-1.16)	4.8 ×10−5	1.09 (1.06-1.13)	1.1 ×10−7	1.10 (1.07-1.13)	1.9 ×10−11	1.05 (1.00-1.09)	4.0 ×10−2	0.12	1.08 (1.06-1.11)	1.2 ×10−11
rs4812829	20 (42422681)	HNF4A	G / A	0.29	0.19	18,186	1.14 (1.08-1.19)	4.5 ×10−7	1.07 (1.04-1.11)	2.8 ×10−5	1.09 (1.06-1.12)	2.6 ×10−10	1.08 (1.02-1.14)	1.0 ×10−2	0.90	1.09 (1.06-1.12)	8.2 ×10−12

Alleles: R=risk, A=alternate. RAF: risk allele frequency in South Asians (SA) and Europeans (EW). Results for Europeans are from the GWA stage of DIAGRAM+. P_hetero is for the comparison between the odds ratios for T2D amongst South Asians in the replication sample, and Europeans in DIAGRAM+.

^*rs1802295 not available on the Illumina 317K array.