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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Pharm Res. 2013 Jun 13;30(8):1947–1955. doi: 10.1007/s11095-013-1036-1

Table II.

Pharmacokinetic parameters for naltrexone (NTX) and its active metabolite, 6-β-naltrexol (NTXol) in human plasma.

NTX NTXol
Group 1 Group 2 Group 3 Group 1 Group 2 Group 3
Css, ng/ml 1.2 (0.3) 1.1 NA 2.0 (0.6) NA NA
Tlag, h 0.4 (0.8) 0 NA 2.8 (1.4) 48.0 NA
Cmax, ng/ml 2.6 (0.7) 2.77 NA 3.5 (1.3) 0.49 NA
Tmax, h 112.0 (62.7) 8 NA 126.0 (41.3) 48.0 NA
Clast, ng/ml 1.4 (0.4) 0 NA 1.89 (1.4) 0 NA
AUC0–174 hr ng•h/ml 196.5 (37.7) 188.1 NA 335.8 (103.6) 18.98 NA

Group 1 received treatment with MN + diclofenac + NTX gel (Group 3 received the same treatment but with no MN application), and Group 2 was treated with placebo gel.