Table 4.

Relative Risk of Depressive Symptoms by eGFR category

eGFR category	Model 1	Model 2	Model 3	Model 4	Model 5
≥90 mL/min/1.73 m2	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)
75–89 mL/min/1.73 m2	0.90 (0.66, 1.23)	1.04 (0.74, 1.46)	1.03 (0.71, 1.50)	1.09 (0.75, 1.57)	1.05 (0.70, 1.57)
60–74 mL/min/1.73 m2	0.84 (0.62, 1.14)	0.97 (0.69, 1.35)	1.08 (0.76, 1.54)	1.12 (0.79, 1.58)	1.09 (0.74, 1.59)
45–59 mL/min/1.73 m2	1.05 (0.75, 1.47)	1.28 (0.88, 1.87)	1.32 (0.88, 1.97)	1.29 (0.87, 1.90)	1.23 (0.81, 1.87)
30–44 mL/min/1.73 m2	1.25 (0.82, 1.90)	1.26 (0.80, 1.99)	1.32 (0.81, 2.14)	1.21 (0.75, 1.96)	1.02 (0.62, 1.68)
≤29 mL/min/1.73 m2	2.02 (1.10, 3.71)*	2.39 (1.27, 4.48)*	2.19 (1.16, 4.13)*	2.04 (1.06, 3.91)*	1.72 (0.89, 3.33)

^*indicates statistical significance (p<0.05 versus reference group)

Note: Modified Poisson regression model. Values are given as relative risk (95% confidence interval). Depressive symptoms defined as Patient Health Questionnaire 8 score 10. Multivariable poisson regression models included the following: in model 1, unadjusted regression analysis; in model 2, patient demographics (age, gender, race/ethnicity, marital status, household income, and education level); in model 3, additional adjustment for demographics and obesity, duration of diabetes and proteinuria; in model 4, fully-adjusted, including medical conditions and cardiovascular comorbidities: cerebrovascular disease, myocardial infarction, peripheral vascular disease, and coronary heart failure; and in model 5, mediation model with additional adjustment for baseline hemoglobin value.

eGFR, estimated glomerular filtration rate;