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. Author manuscript; available in PMC: 2014 Mar 5.
Published in final edited form as: Nature. 2013 Aug 21;501(7465):52–57. doi: 10.1038/nature12479

Figure 5. Nociceptor ablation leads to increased local inflammation and lymphadenopathy following S. aureus infection.

Figure 5

(a) Nav1.8-Cre/DTA neurons lack hk-bacteria responses. (b) Infection-induced mechanical (p=0.0027), heat hypersensitivity (p=0.0003) in Nav1.8-Cre/DTA mice (n=10 mechanical, n=6 heat) and Control littermates (n=12 mechanical, n=6 heat). ***p<0.001. (c-e) Parameters analyzed 24 hours post-infection. (c) Tissue swelling: Nav1.8-Cre/DTA (n=23), Control (n=19). (d) Plantar neutrophils/monocytes: Nav1.8-Cre/DTA: n=4 uninfected, n=15 infected; Control: n=4 uninfected, n=19 infected. (e) Popliteal lymph node images (infected), lymph node cellularity (Nav1.8-Cre/DTA: n=9 uninfected, n=10 infected; Control: n=9 uninfected, n=11 infected), and lymph node monocyte/macrophage (Mϕ), neutrophil (Nϕ), T, B cell subsets (n=5 each). Error bars, mean±s.e.m.