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. Author manuscript; available in PMC: 2014 Mar 5.
Published in final edited form as: Nature. 2013 Aug 21;501(7465):52–57. doi: 10.1038/nature12479

Figure 6. Nociceptor derived neuropeptides regulate innate immune activation.

Figure 6

(a) Nav1.8-Cre/TdTomato+ DRG, trigeminal, nodose ganglia neurons were purified by flow cytometry (gates shown). (b) Top 30 nociceptor-expressed neuropeptides and myeloid immune cell-expressed neuropeptide receptors, shown from maximum to minimum. (c) Hla, S. aureus supernatant, and capsaicin (100 nM) induce DRG neuron CGRP release. **p<0.01; ***p<0.001. (d) TNF-α production by hk-S. aureus or Lipoteichoic acid stimulated macrophages was suppressed by CGRP, Sst, Gal (neuropeptide concentrations, 1 μM; *p<0.05). (e) CGRP injection decreased lymphadenopathy 24 hours post-S. aureus infection. Error bars, mean±s.e.m.