Table 4. Genotyping Frequencies and Association of Genotype with Patients’ D’Amico Risk Class.
| SNP | Associated Gene |
Location | Genotype | No. | Intermediate /High |
RR | 95% CI | P Chisq | FDR | Median of TT (ng/dL) |
Q1, Q3 | P Wilcox |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs11252845 | AKR1C1 | 5′ upstream | CC | 438 | 250 (55.0%) | 1 | 0.005 | 0.248 | 444.4 | 336.9, 578.6 | 0.124 | |
| CT/TT | 52 | 17 (34.0%) | 0.62 | 0.40-0.88 | 400.5 | 303.6, 545.3 | ||||||
|
| ||||||||||||
| rs2045100 | UGT2B15 | Intron 1 | TT | 395 | 212 (55.4%) | 1 | 0.007 | 0.248 | 431.1 | 323.0, 565.1 | 0.259 | |
| AT/AA | 31 | 9 (30.0%) | 0.54 | 0.28-0.87 | 466.9 | 349.2, 606.7 | ||||||
|
| ||||||||||||
| rs7932905 | HSD17B12 | Intron 1 | AA | 140 | 85 (59.9%) | 1 | 0.008 | 0.248 | 432.6 | 308.3, 564.6 | 0.743 | |
| AG | 245 | 133 (53.2%) | 0.89 | 0.74-1.07 | 442.4 | 351.1, 579.8 | ||||||
| GG | 93 | 41 (39.1%) | 0.65 | 0.48-0.86 | 427.9 | 337.1, 555.6 | ||||||
RR, relative risk; CI, confidential level; TT: total testosterone; Q1, Q3: 25%, 75%