Organization of the flavivirus genome. A) RNA genome including the 5’ and 3’ untranslated regions (UTR) and coding regions for the structural and non-structural proteins. B) Polyprotein processed by both virus-encoded and host proteases resulting in three structural proteins (capsid (C), membrane (M), and envelope (E)) and seven non-structural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5). C) Diagram indicating the alterations to the DENV genome for generation of several live attenuated virus vaccine candidates. See text for a brief description of the vaccines mentioned in this panel.