Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic representation of E. coli DHFR reaction (12) and S. pneumoniae DHFR at pH 7.0. Highlighted with bold italic are the rate constants measured from experiments for S. pneumoniae DHFR. E = DHFR; NH = NADPH; H2F = 7, 8-dihydrofolate; H4F = tetrahydrofolate; N+ = NADP+
