Table 3.
Causality and severity of outcomes of patients with duloxetine hepatotoxicity
| Patient | DILIN Causality Score | Expert RUCAM score | DILIN severity scale |
|---|---|---|---|
| 1 | 1 | 9 | 4 |
| 2 | 1 | 8 | 3 |
| 3 | 2 | 8 | 4 |
| 4 | 2 | 5 | 3 |
| 5 | 2 | 7 | 3 |
| 6 | 4*(possible) | 8 | 1 |
| 7 | 2 | 6 | 2 |
The DILIN causality score ranges from 1–5 [3- probable; 5- unlikely]. The DILIN severity of the DILI episode is categorized on a scale of 1(mild) to5 (fatal resulting in death or liver transplantation).
*
Please refer to the narrative for Case 6 for reasons resulting in assignment of causality score of 4.