Figure 4.

No effect of Hdac1 or Hdac2 KO on motor learning or episodic memory. A, B, Latencies to fall off the rotarod were not different for Hdac1 (A, n = 12) or Hdac2 (B, n = 12) KOs compared with CTL (n = 12, n = 10), indicating normal motor coordination and learning. C, SOR/NOR task performance in Hdac1 KO mice (C, n = 11) was similar to CTL (n = 10). D, E, Hdac2 KO mice (n = 10) did not exhibit differential memory for was similar to CTL (n = 10, n = 12) as indicated by no difference in the ratio of time spent with the moved (spatial) or novel object when provided with either 10 or 3 min training sessions for object familiarization. Hyphenated line indicates chance performance.