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. Author manuscript; available in PMC: 2014 Aug 8.
Published in final edited form as: J Med Chem. 2013 Jul 22;56(15):6108–6121. doi: 10.1021/jm400823w

Scheme 1. Synthesis of L8 and ReL8.

Scheme 1

i. N-Boc-propargylglycine, Cu(OAc)2, Sodium ascorbate, H2O/t-BuOH (1:1), rt; ii. 20% piperidine/DMF; iii. 2, DMF, DIEA, rt; iv. TFA/CH2Cl2/TES; v. [Re(CO)3(H2O)3]Br, MeOH/H2O.