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. Author manuscript; available in PMC: 2014 Aug 8.
Published in final edited form as: J Med Chem. 2013 Jul 22;56(15):6108–6121. doi: 10.1021/jm400823w

Scheme 4. Synthesis of L11.

Scheme 4

(i) 20% piperidine in DMF; (ii) Fmoc-Gly-OH, HBTU, DIEA, DMF; (iii) 20% piperidine in DMF; (iv) Fmoc-Gly-OH, HBTU, HOBT, DIEA, DMF; (vii) S-Trityl-CH2CO2-NHS, DIEA, DMF.