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. Author manuscript; available in PMC: 2014 Aug 8.
Published in final edited form as: J Med Chem. 2013 Jul 22;56(15):6108–6121. doi: 10.1021/jm400823w

Table 2.

Biodistribution of [99mTc]L8 in tumor bearing mice.a

0.5 h 1 h 2 h 5 h

blood 1.35 ± 1.22 0.46 ± 0.20 0.19 ± 0.05 0.13 ± 0.05
heart 0.65 ± 0.26 0.52 ± 23 0.22 ± 0.14 0.08 ± 0.01
lung 2.47 ± 0.83 1.78 ± 0.29 0.92 ± 0.14 0.30 ± 0.09
liver 28.85 ± 17.93 11.36 ± 1.57 6.11 ± 0.66 3.24 ± 0.39
stomach 0.73 ± 0.16 0.41 ± 0.21 0.17 ± 0.05 0.20 ± 0.13
pancreas 1.08 ± 0.18 0.43 ± 0.12 0.25 ± 0.12 0.10 ± 0.06
spleen 21.11 ± 8.49 12.28 ± 2.99 4.42 ± 1.68 1.83 ± 1.52
fat 1.08 ± 0.49 0.66 ± 0.06 0.33 ± 0.12 0.12 ± 0.04
kidney 122.70 ± 14.73 119.15± 0.01 116.2 ± 14.2 55.31 ± 1.15
muscle 0.71 ± 0.27 0.70 ± 0.52 0.23 ± 0.16 0.08 ± 0.04
small intestine 2.26 ± 1.27 1.35 ± 0.19 0.69 ± 0.20 0.14 ± 0.05
large intestine 0.57 ± 0.15 0.29 ± 0.06 0.81 ± 0.51 1.31 ± 0.9
bladder 1.72 ± 0.86 7.70 ± 8.30 1.22 ± 0.33 1.11 ± 0.56
PC-3 PIP 28.31 ± 4.38 28.05 ± 2.04 26.29 ± 7.45 23.22 ± 6.02
PC-3 flu 0.50 ± 0.07 0.24 ± 0.06 0.19 ± 0.08 0.07 ± 0.01
PIP: flu 53.95 ± 1.61 112.59 ± 30.47 103.90 ± 32.36 307.24 ± 25.25
PIP: blood 32.14 ± 4.75 41.24 ± 26.57 108.72 ± 28.78 178 ± 79.79
PIP: muscle 42.87 ± 29.34 38.44 ± 17.81 103.99 ± 57 141.58 ± 88.36
a

Values expressed are in % ID/g ± standard deviation. N = 4 for all tissues