Table 4.
Biodistribution of [99mTc]L15 in tumor-bearing mice.a
30 min | 1 h | 2 h | 5 h | |
---|---|---|---|---|
|
||||
blood | 0.53 ± 0.15 | 0.54 ± 0.07 | 0.24 ± 0.35 | 0.19 ± 0.25 |
heart | 0.72 ± 0.23 | 0.72 ± 0.09 | 0.17 ± 0.11 | 0.23 ± 0.06 |
lung | 2.83 ± 0.81 | 2.59 ± 0.80 | 1.58 ± 0.45 | 1.80 ± 0.14 |
liver | 0.62 ± 0.23 | 0.39 ± 0.05 | 0.26 ± 0.09 | 0.24 ± 0.07 |
stomach | 1.01 ± 0.83 | 1.56 ± 0.65 | 1.40 ± 0.92 | 0.45 ± 0.23 |
pancreas | 1.23 ± 0.56 | 2.36 ± 2.43 | 0.54 ± 0.20 | 0.55 ± 0.09 |
spleen | 24.05 ± 9.01 | 25.66 ± 4.99 | 7.55 ± 2.14 | 10.10 ± 2.34 |
fat | 0.85 ± 0.60 | 1.45 ± 0.44 | 0.10 ± 0.19 | 0.35 ± 0.61 |
kidney | 242.68 ± 36.55 | 346.60 ± 28.12 | 270.08 ± 44.35 | 261.65 ± 26.90 |
muscle | 0.83 ± 0.54 | 0.86 ± 0.02 | 0.13 ± 0.31 | 0.34 ± 0.12 |
sml. intetine | 0.46 ± 0.07 | 0.53 ± 0.36 | 0.20 ± 0.18 | 0.38 ± 0.18 |
lrg intestine | 0.48 ± 0.04 | 0.47 ± 0.21 | 0.06 ± 0.12 | 0.25 ± 0.05 |
bladder | 1.09 ± 0.43 | 1.24 ± 0.86 | 0.25 ± 0.47 | 2.42 ± 1.41 |
PC3 PIP | 20.52 ± 2.12 | 23.44 ± 3.82 | 18.27 ± 3.35 | 28.01 ± 5.81 |
PC3 flu | 0.41 ± 0.06 | 0.43 ± 0.09 | 0.29 ± 0.13 | 0.38 ± 0.19 |
PIP: flu | 48.18 ± 7.67 | 57.40 ± 7.12 | 70.14 ± 24.93 | 92.48 ± 40.51 |
PIP: blood | 42.49 ± 21.24 | 42.57 ± 11.64 | 67.0328 ± 0.00 | 63.08 ± 19.84 |
PIP: muscle | 63.69 ± 80.92 | 18.65 ± 16.57 | 73.65 ± 0.00 | 85.42 ± 27.06 |
Values expressed are in % ID/g ± standard deviation. N = 4 for all tissues