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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Bioorg Med Chem. 2013 Jul 2;21(17):5029–5038. doi: 10.1016/j.bmc.2013.06.052

Scheme 1.

Scheme 1

Synthesis of monovalent constructs 12a–15a and divalent constructs 12b–15b.a

aCompounds 8, 9, and 10 were obtained as complex mixtures of stereoisomers and regioisomers. Compounds 12a–15a and 12b–15b, derived from 9 and 10, respectively, are likewise assumed to be the related mixtures of stereoisomers and regioisomers.