Table 2.
Hemodynamic measurements 22h after CASP or sham operation
| WT | NOS3KO | |||
|---|---|---|---|---|
| n | sham 5 |
CASP 8 |
sham 6 |
CASP 7 |
| HR, bpm | 567±11 | 567±11 | 538±13 | 547±21 |
| LVESP, mmHg | 111±4 | 77±6 | 131±6# | 84±10* |
| LVEDP, mmHg | 2±0 | 5±1 | 3±0 | 8±2*# |
| dP/dtmax, mmHg/s | 19768±1084 | 11667±1726* | 17637±369 | 6527±795*# |
| dP/dtmin, mmHg/s | −9974±875 | −9809±1071 | −11363±1505 | −5013±728*# |
| EF, % | 61±4 | 45±3* | 69±4 | 34±4*# |
| CO, ml/min | 14.8±1.6 | 17.5±1.8 | 13.5±2.1 | 8.1±1.3*# |
| dP/dtmax/IP, s−1 | 222±8 | 219±8 | 201±15 | 135±21*# |
| Ea, mmHg/μL | 3±2 | 3±1 | 5±1 | 6±1# |
| Ees, mmHg/μL | 27±6 | 16±3 | 30±6 | 10±1* |
| Ea/Ees | 0.1±0.1 | 0.2±0.1 | 0.2±0.1 | 0.6±0.1*# |
| τ, msec | 5.5±0.2 | 4.6±0.2 | 5.5±0.1 | 8.5±1.2*# |
Values are means ± SE. HR, heart rate; LVESP, left ventricular end-systolic pressure; LVEDP, left ventricular end-diastolic pressure; dP/dtmax, maximum rate of developed left ventricular pressure; dP/dtmin, minimum rate of developed left ventricular pressure; EF, ejection fraction; CO, cardiac output; dP/dtmax/IP, dP/dtmax divided by instantaneous pressure; Ea, arterial elastance; Ees, left ventricular end-systolic elastance; Ea/Ees, ratio of Ea to Ees; τ, time constant of isovolumic relaxation.
*
P<0.05 vs sham-operated mice of the same genotype.
#
P<0.05 vs WT mice with the same operation.