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. Author manuscript; available in PMC: 2013 Sep 16.
Published in final edited form as: Behav Brain Res. 2011 Mar 31;222(1):230–235. doi: 10.1016/j.bbr.2011.03.052

Figure 1.

Figure 1

Downregulation of hypothalamic IRs does not affect HPA axis responses to acute stress. Virus-treated rats were subjected to an acute (30 minute) restraint stress challenge to determine if downregulation of hypothalamic IRs affected stress reactivity. Tail bleeds were performed to determine baseline plasma CORT levels (basal), peak restraint stress-induced plasma CORT levels (i.e. 30 min stress) and plasma levels 1 hour following termination of stress (i.e. post-stress). Basal, stress and post-stress plasma CORT levels did not differ in hypo-IRAS rats when compared to hypo-Con rats, suggesting that downregulation of hypothalamic IRs does not affect HPA axis responses to acute stress. Data based upon eight rats per group.