Table 4.
Strategies for monitoring patients with classic galactosemia during Childhood
| COUNTRY (City) |
CLINICAL PARAMETERS TO FOLLOW | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| GROWTH AND DEVELOPMENT |
LIVER FUNCTION |
RENAL FUNCTION |
SCHOOL PERFORMANCE |
CALCIUM HOMEOSTASIS |
OPHTALMOLOGIC EVALUATION |
BLOOD/URINE PARAMETERS |
ENDOCRINE ASSESSMENT |
SPEECH EVALUATION |
NEUROLOGICAL DEVELOPMENT |
|
| UK (Manchester) |
|
|
Urinary galactitol (few centres) |
|
||||||
| Netherlands (Amsterdam) |
|
|
|
in case of residual cataract |
Gal-1P(used less frequently nowadays) |
|
|
|
||
| Mexico (Mexico City) |
Total blood galactose and urinary galactitol |
|||||||||
| Croatia (Zagreb) |
|
|
|
|
Liver function tests |
|
||||
| Italy (Padova) |
|
|
|
Gal-1P, total galactose, sialotransferrin profile |
|
|||||
| Spain (Santiago de Compostela) |
|
|
|
|
Gal-1P |
|
||||
| Germany (Düsseldorf) |
|
|
Gal-1P Urinary galactitol |
|
|
|||||
| South Africa (Cape Town) |
NO INFORMATION | |||||||||
| United States (Cincinnati) |
|
|
||||||||
| United States (Salt Lake City) |
|
Yearly for first 2 years, then every 3-5 years (if normal) |
Gal-1P | after age 8 in girls |
|
|||||
| United States (Boston) |
|
|
|
Gal-1P, galactitol, 25-0 H vitD |
FSH, LH, estradiol tested at 1- 2yrs |
|
||||
| Argentina (Buenos Aires) |
|
|||||||||
| Philippines (Manila) |
|
|
|
|
Total blood galactose every 3 months |
|
|
|
||