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. 2012 Feb 7;302(8):E1009–E1015. doi: 10.1152/ajpendo.00666.2011

Fig. 4.

Fig. 4.

Induction of PTHrP expression depends on 5-HT2 but not 5-HT7. A: lactation levels of PTHrP were similar by immunostaining in wild-type (5-HT7+/+) and 5-HT7 knockout (5-HT7−/−) mammary gland epithelium (representative of 3 replicate glands of each genotype). B: PTHrP mRNA expression levels in HC11 cells (lactogen differentiated) treated with specified concentrations of 5-HT2 agonist (BW-723C86, closed symbols) or antagonist (SB-204741; open symbols). PTHrP (C) and Runx2 (D) mRNA expression levels in MDA-MB-231 cells treated with 5-HT2 agonist (closed symbols) or antagonist (open symbols). Data are represented as individual values of log-transformed data with lines drawn through the means (*P < 0.05, **P < 0.01, ***P < 0.001).