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Schema depicting proposed relationship between breast and bone cells. TPH1 activity in lactating and cancer cells catalyzes 5-HT biosynthesis. Autocrine 5-HT (solid red arrow) drives PTHrP secretion via activation of type 2 receptors. For the sake of simplicity, potential roles of Runx2 are omitted. OB signaling activates OC functions (solid black line). Additional 5-HT actions via paracrine signaling to OBs and OCs may be important in cancer (broken lines).
