FIGURE 7.

CD4⁺CD25⁺ Foxp3⁺ T cells from NIMA mice can transfer tolerance to K^b+ allografts. CD4⁺CD25⁻ and CD4⁺CD25⁺ T cells were purified from either NE (circles), IMA (squares), or NIMA (triangles) mice. Each T cell subset (5 × 10⁵ cells) was separately injected i.v. into naive CBA mice, which received a CBK heart transplant 3 d later. Control mice, which received no T cells, were also tested (diamonds). The effects of adoptive transfer of CD4⁺CD25⁻ (open symbols) and CD4⁺CD25⁺ (solid symbols) T cells on graft survival were monitored. Each point corresponds to the survival data from a single mouse. Horizontal bars represent the MST (days).