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. Author manuscript; available in PMC: 2014 Sep 15.
Published in final edited form as: J Immunol. 2013 Aug 7;191(6):3254–3263. doi: 10.4049/jimmunol.1300722

Figure 2. PPS14+[PspA] beads induce PPS14-specific Ig responses in a T cell dependent manner.

Figure 2

BALB/c and BALB/c athymic nude mice (n=7), were immunized on days 0 and 14 (arrows) with ≈ 2×108 latex beads, coated with the Ag combinations indicated, in alum + CpG-ODN. Each dose of the corresponding beads contained approximately 230 ng of serologically active PPS14 and/or the equivalent of 425 ng of total PPS14-PspA conjugate. Beads used in this experiment are the same shown in Figure 1A. Serum titers of PPS14-specific and PspA-specific IgG and IgM were determined by ELISA. Values are expressed as geometric mean ± SEM. *p < 0.05 (between the responses elicited in BALB/c versus athymic nude mice), #p < 0.05 (titer−1 relative to the previous bleeding of each mouse group).