Table 4. Adjusted Multivariate Models Exploring the Association between BK Viremia and Subsequent Hemorrhagic Cystitis*.
Variable | Peak BK Viremia 1 to 9999 copies/mL | Peak BK Viremia ≥ 100,000 copies/mL | ||||||
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Model 1 | Model 2 | Model 3 | Model 4 | Model 1 | Model 2 | Model 3 | Model 4 | |
BK viremia | 5.2 (1.9 to 14.5) p<.01 | 4.8 (1.7 to 13.6) P <.01 | 6.4 (2.2 to 19.0) P<.01 | 4.2 (1.3 to 13.7) P = .02 | 41.4(5.1 to 336) P<.01 | 44.2 (5.6 to 346) P<.01 | 67.9 (7.1 to 651) P <.01 | 116.8 (12.0 to 1136) P <.01 |
Age > 7 yr | 3.1 (1.0 to 9.4) P = .05 | 2.9 (.9 to 8.9) P = .06 | 3.8 (1.2 to 12.3) P = .02 | 7.7 (1.9 to 31.8) P <.01 | 3.5 (1.1 to 10.9) P = .03 | 3.9 (1.2 to 12.6) P = .02 | 3.5 (1.1 to 11.3) P = .04 | 9.2 (2.3 to 37.4) P <.01 |
Antithymocyte globulin conditioning | - | 2.9(1.1 to 7.9) P = .04 | 33(1.2 to 9.2) P = .02 | 2.3 (.8 to 6.9) P = .13 | - | 3.3(1.2 to 9.0) P = .02 | 3.7 (1.3 to 10.5) P = .01 | 2.7 (.9 to 8.3) P = .09 |
Platelet engraftment (> 50,000/μL) | - | - | .2(.05 to .9) P = .03 | .3 (.06 to 1.3) P = .ll | - | - | 0.2 (.04 to 1.2) P =.08 | 0.3 (.06 to 1.8) P = .21 |
HHV-6 viremia | _ | _ | _ | 7.2 (1.8 to 29.8) P <.01 | _ | _ | _ | 16.9 (4.2 to 68.1) P <.01 |
Data presented as hazard ratios (95% confidence intervals). Bold typeface indicates statistical significance.
Adjusted for all variables listed. Busulfan, cyclophosphamide, type of conditioning (myeloablative versus reduced intensity), and posttransplantation thrombotic microangiopathy were not significant covariates when added to the models.