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. Author manuscript; available in PMC: 2013 Sep 16.
Published in final edited form as: Mol Immunol. 2012 May 10;52(1):9–18. doi: 10.1016/j.molimm.2012.04.004

Figure 4. The reduction in global perturbation index between 4 and 10 weeks of age is not reflected by a reduction in total perturbation index of individual Vβ families.

Figure 4

The total perturbation index (%) for each Vβ family in each mouse was calculated for 4 (n=11) and 10 week old mice (n=20), and mice at diabetes onset (n=14). The mean and SD is shown for each Vβ family, and each dot represents an individual mouse. Vβ4 is significantly less perturbed at 10 weeks than at 4 weeks of age (A), while the total perturbation index of Vβ8.2 and Vβ8.3 increased during disease progression (B). Other Vβ families are either more perturbed at T1D onset (C) or do not change during disease progression (D). Significant changes between time points was calculated using unpaired t test and are shown as *** p<0.0001; ** p<0.001 or * p<0.01.