Figure 1. mRNA expression of BA transporters in livers and ilea of WT and Oatp1a4-null mice.
Total RNA was isolated from livers and ilea of WT and Oatp1a4-null mice. The mRNA expression of hepatic basolateral uptake transporters (A), hepatic basolateral efflux transporters (B), hepatic canaliculus efflux transporters (C), intestinal BA transporters (D) and intestinal cholesterol transporters (E) were analyzed by multiplex suspension array. The mRNAs were normalized to Gapdh. All data are expressed as mean ± S.E. for five mice in each group. Asterisks (*) indicate statistically significant difference between WT and Oatp1a4-null mice within the same gender (p<0.05).