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Effect of 50 mM 1,3-dimethylurea (DMU) on urea fluxes in the human colon. Urea flux in both the absorptive and secretory directions were significantly inhibited by DMU in human ascending colon. In contrast, urea flux in human descending colon was completely unaffected by DMU in either direction. *P < 0.05 vs. control data by unpaired t-test (n = 6).
