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. 2011 Jul 28;111(4):1125–1133. doi: 10.1152/japplphysiol.01340.2010

Fig. 1.

Fig. 1.

Changes in cardiovascular function after metoprolol administration in mice. Heart rate (A), stroke volume (B), and cardiac output (C) are significantly reduced while systemic vascular resistance (SVR; D) is increased following metoprolol injection (3 mg/kg). Average end-systolic and diastolic pressures and volumes (E–H) were not affected by metoprolol treatment (n = 6; *P < 0.05). bpm, Beats/min.