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. 2012 Apr 5;112(12):2110–2120. doi: 10.1152/japplphysiol.01383.2011

Fig. 1.

Fig. 1.

High renin-angiotensin-aldosterone system (RAAS) activity-induced hypertrophy in spontaneously hypertensive rats (SHR) is reversed by angiotensin converting enzyme (ACE) inhibition. Aldosterone plasma levels, expressed as percentage of control values (A), systolic blood pressure values (B), and hypertrophic parameters (C–G) are shown. C: heart weight-to-tibia length ratio (HW/TL). D and E: cross-sectional area (CSA) of the myocytes. F and G: left ventricular mass. Representative echocardiographic images (F) and left ventricular mass normalized by tibia length [left ventricular mass index (LVMI); G] are significantly increased in SHR. Enalapril (Ena) treatment prevents the increments in all of the parameters studied (A–G). Sp Th, septum thickness; Dd, diastolic diameter; Pw Th, posterior wall thickness. Overall data are means ± SE; n, no. of animals in each experimental group (in parentheses). *P < 0.05 vs. control. §P < 0.05 +Ena vs. SHR.