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Both pretreatment and posttreatment with RyR inhibitors attenuates TLCS-induced acinar cell injury. Dantrolene (100 μM, A) or ryanodine (100 μM, B) was administered at the times indicated relative to the time of TLCS. RyR inhibition reduced cell injury in both pre- or post-TLCS treatment schemes, although the reduction was greater with pretreatment (n = 6). P < 0.05, compared with the control (#) and TLCS alone (*).
