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RyR inhibition attenuates acinar cell injury due to taurocholic acid (TC), taurochenodeoxycholic acid (TCDC), and taurodeoxycholic acid (TDC). Isolated acinar cells were pretreated with either dantrolene (100 μM) or ryanodine (100 μM) for 30 min before a 2-h incubation with the bile acids (n = 3). P < 0.05 compared with the control (#) and each corresponding bile acid (*).
