Fig. 4.

PGIS overexpression decreases bleomycin-induced lung consolidation. PGIS OE⁺ mice and littermate control PGIS OE⁻ mice were intranasally administered 0.08 U of bleomycin at day 0. Mouse lungs were harvested at days 6 and 14. The lung sections of the paraffin-embedded tissue were stained with hematoxylin and eosin. The lung tissue consolidation was scored by a pathologist who was blinded to the sample identifications. Representative pathological images of the lung sections are shown. Data shown are the means ± SE, n = 5–6 mice. *P < 0.05 vs. PGIS OE⁻/bleomycin at the same time point.