Table 1.

Characteristics of Ossabaw miniature pigs at time of euthanasia

	Control Chow Group (n = 7)	Atherogenic Diet Group (n = 5)	M-Ath Diet Group (n = 6)
Sex, male/female	2/5	0/5	0/6
Weight at euthanasia, kg	53 ± 2	94 ± 4*	86 ± 14*
Mean weight gain, kg	14 ± 1	54 ± 4*	38 ± 13
Glycemic measures
Fasting glucose, mg/dl	79 ± 3	87 ± 2	88 ± 6
Fasting insulin, μU/ml	11 ± 2	15 ± 1	18 ± 3
HOMA	2 ± 0.3	3 ± 0.3	4 ± 1
Lipid measures
Total cholesterol, mg/dl	81 ± 4	328 ± 32*	629 ± 80*†
LDL cholesterol, mg/dl	36 ± 4	242 ± 27*	520 ± 68*†
HDL cholesterol, mg/dl	41 ± 4	79 ± 6*	83 ± 5*
LDL/HDL Ratio	1 ± 0.2	3 ± 0.3*	6 ± 1*†
Triglycerides, mg/dl	24 ± 3	37 ± 2	130 ± 17*†
Liver biochemistries
AST, U/l	32 ± 3	27 ± 1	100 ± 21*†
ALT, U/l	46 ± 7	33 ± 1	41 ± 12
ALP, U/l	73 ± 11	110 ± 10	273 ± 110*
Total bilirubin, mg/dl	0.2 ± 0.02	0.2 ± 0.02	0.3 ± 0.04

Values expressed are means ± SE.

^*P < 0.05 vs. control chow group.

^†P < 0.05 vs. atherogenic diet group.

M-Ath, modified atherogenic; HOMA, homeostatic model assessment method; LDL, low-density lipoprotein; HDL, high-density lipoprotein; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase.