Table 4.

Summary of 20 differentially expressed priority 1 proteins (q < 0.05)

		Mean Protein Intensity ± SE (log2)*
Protein ID	Annotation	Maximum Fold Change	Minimum q value	Control Chow Group	Atherogenic Diet Group	M-Ath Diet Group	Protein Function
50657386	Apolipoprotein C-III	2.20707799	0.0394173	13.89 ± 0.23	14.61 ± 0.28	15.03 ± 0.23†	Lipoprotein component important for triglyceride exchange, transport and metabolism
2388609	Apolipoprotein E	2.13375032	0.0067329	13.35 ± 0.17	13.96 ± 0.20	14.45 ± 0.17†	Lipoprotein component important for cholesterol exchange, transport and metabolism
47523674	Apolipoprotein E precursor	2.13318557	0.0067329	13.29 ± 0.17	13.91 ± 0.20	14.38 ± 0.17†	Lipoprotein component important for cholesterol exchange, transport and metabolism
194033903	Orosomucoid 1	2.10644948	0.005958	14.65 ± 0.12	15.73 ± 0.14†	15.43 ± 0.12†	Acute phase protein and immune system regulation
951375	Apolipoprotein B	1.82428754	0.0018515	13.17 ± 0.10	13.55 ± 0.12	14.04 ± 0.10†	LDL component important for cholesterol exchange, transport and metabolism
55742849	Serum amyloid P component	1.63619691	0.0067329	13.75 ± 0.11	13.71 ± 0.13	13.04 ± 0.11†‡	Immune system regulation and comprises extracellular matrices
47523188	Secreted folate binding protein	1.62591648	0.0067329	13.06 ± 0.11	13.18 ± 0.13	13.76 ± 0.11†	Transport, protection and delivery of folic acid in extracellular fluids
47523508	Transthyretin	1.48109011	0.0024211	15.75 ± 0.07	15.24 ± 0.08†	15.18 ± 0.07†	Carrier of thyroxine (T4) hormone and aggregates as amyloid structures
47523688	Folate receptor 1	1.44460772	0.0214633	14.74 ± 0.10	14.83 ± 0.12	15.27 ± 0.10†	High affinity folate receptor responsible for transport of folic acid into cells
1871390	Endopeptidase 24.16 type M2	1.42329757	0.0280159	16.42 ± 0.08	16.61 ± 0.09	16.10 ± 0.08‡	Metalloendopeptidase that preferentially cleaves short peptides
51491902	Ovarian and testicular apolipoprotein N	1.4186694	0.0384757	14.15 ± 0.08	14.35 ± 0.10	13.85 ± 0.08‡	Lipoprotein component found in serum and synthesized in reproductive tissues
167621416	Paraoxonase 1	1.39969355	0.0041129	14.09 ± 0.05	14.35 ± 0.06	13.87 ± 0.05‡	Degrades oxidized lipids and anti-inflammatory actions
194037847	Similar to α-2-macroglobulin precursor	1.37850584	0.0280159	14.50 ± 0.07	14.39 ± 0.08	14.85 ± 0.07†‡	Acute phase protein/immune system regulation and coagulation
188035850	β-2-Microglobulin	1.35057716	0.0293498	13.60 ± 0.07	14.03 ± 0.08†	13.92 ± 0.07†	Component of MHC molecules involved in immune system regulation
190360623	Retinoic acid-induced 14	1.34441846	0.0067964	13.60 ± 0.07	13.40 ± 0.08	13.17 ± 0.07†	Developmental protein expressed in reproductive tissues and induced by retinoic acid
156120138	Complement component 2	1.28693895	0.0076254	13.62 ± 0.06	13.89 ± 0.07	13.98 ± 0.06†	Immune system regulation and inflammation
47523636	Fumarate hydratase	1.26642198	0.0067329	14.24 ± 0.05	14.06 ± 0.06	13.90 ± 0.05†	Enzyme that metabolizes fumarate to malate/involved in amino acid metabolism
47523152	p101 protein	1.23724734	0.0418707	14.76 ± 0.05	14.81 ± 0.06	14.51 ± 0.05†‡	Regulatory subunit of the Phosphoinositide 3-Kinase γ enzyme/inflammatory processes
194040626	Carboxypeptidase B2 (plasma)	1.22488625	0.0077865	14.37 ± 0.04	14.54 ± 0.04	14.24 ± 0.04‡	Pro-thrombotic enzyme that inhibits fibrinolysis
148223227	Complement component C8G	1.16525069	0.0281536	13.46 ± 0.03	13.24 ± 0.04†	13.30 ± 0.03†	Immune system regulation and inflammation

^*Log2 scale: a difference of one unit is equivalent to a twofold change.

^†q < 0.05 vs. control chow group;

^‡q < 0.05 vs. Atherogenic Diet Group.

MHC, major histocompatability complex.