Fig. 7.
Glomerular sieving coefficient for Ficoll-70 (θFicoll-70) in gonadally intact CA/CPR-naive mice (Naive-INT), ovariectomized CA/CPR-naive mice (Naive-OVX), and CA/CPR-treated mice at 2, 6, 12, and 24 h following arrest and resuscitation. At the specified time point, mice were reanesthetized and administered fluorescent-labeled Ficoll-70, bumetanide, and intravenous 0.9% sodium chloride solution. Eighty minutes later, the mice were euthanized and blood and serum fluorescence were evaluated to determine Ficoll-70 concentration. Removal of physiological estrogen by ovariectomy did not alter θFicoll-70. Twenty-four hours following CA/CPR, θFicoll-70 was significantly elevated, but then rapidly declined to values similar to those found in CA/CPR-naive animals. Numbers in bars are n.