Table 2.
Effects of angiotensin II, PD-123319, and losartan on hemodynamic and electrophysiological parameters
| Baseline | AGII | P Value | Baseline | PD | P Value | Baseline | Losartan | P Value | |
|---|---|---|---|---|---|---|---|---|---|
| SBP, mmHg | 116±3 | 181±6 | <0.01 | 120±8 | 114±9 | NS | 132±5 | 116±7 | NS |
| DBP, mmHg | 79±2 | 125±5 | <0.01 | 82±6 | 77±6 | NS | 87±3 | 77±6 | NS |
| MAP, mmHg | 92±2 | 144±5 | <0.01 | 98±3 | 95±3 | <0.01 | 101±3 | 90±5 | NS |
| ERP, ms | 155±2 | 153±2 | NS | 150±3 | 151±3 | NS | 152±4 | 154±5 | NS |
| PT, mV | 41±3 | 44±3 | NS | 49±4 | 50±3 | NS | 52±7 | 54±8 | NS |
| IS, % | 51±3 | 54±3 | NS | 59±4 | 61±4 | NS | 55±1 | 55±1 | NS |
| CV, m/s | 1.04±0.1 | 0.94±0.1 | NS | 0.75±0.1 | 0.78±0.1 | NS | 0.75±0.1 | 0.78±0.1 | NS |
Values are means ± SE.
SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; ERP, effective refractory period; PT, pacing threshold; IS, infarct size; CV, longitudinal conduction velocity; AGII, angiotensin II; PD, PD-123319; NS, nonsignificant.