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Schematic model for PRMT5-dependent transcriptional repression of C/EBPβ target genes. CDK-containing Mediators are recruited to the TAD domain of C/EBPβ target genes, where they associate with PRMT5 and WDR77. PRMT5 then symmetrically dimethylates histone H4 arginine 3 (H4R3me2s), leading to recruitment of the DNA methyltransferase DNMT3A and ultimately to transcriptional repression of C/EBPβ target genes.
